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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are usually characterized by a focus on the practical aspects of the research design, like the recruitment and consent process, adherence, and the use of standard equipment.

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Pragmatic, a software company, offers a variety of casino games to online gambling platforms. Its iGaming software is used by top operators as well as land-based casinos. The company provides front-end design tools, analysis tools, promotions, marketing and payment systems, as well as security, customer service, and bug reporting. Additionally, the company offers its players a safe and secure environment with high-quality graphics as well as games.

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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be reliable and lessen the chance of bias is also essential. However, too much heterogeneity can lead to problems with the design of the trial.

Pragmatic Play, one of the major players in the live casino market offers a variety of classic table games like Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic gambling experience, as well a full selection of virtual betting options. The company also offers a variety of games that make online gambling more fun and interactive. Some of these shows are hosted live and others are hosted by famous personalities from the field.

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Pragmatic Play is known for its top-quality games and also for providing an outstanding user experience. Its software is designed to work on mobile devices and supports various languages. It has earned itself the status of one of the leading casino gaming platforms despite its relatively young age. The most recent releases include Wolves, a 5-reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policy makers to inform their decision making. They can also be a great method of determining the cause-effect relationship between an intervention and its outcomes. They should, however, not be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a practical trial, including the recruitment process, the design and implementation of the intervention, and monitoring.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. However, it is important to remember that the majority of these trials were conducted in primary care settings.