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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are typically characterized by a focus on the practical aspects of the study design, including recruitment and consent as well as adherence to the use of routinely available equipment.

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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid, and it also helps to reduce bias in the results. Too much heterogeneity, however, can cause problems with the design of the trial.

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The goal of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are typically commissioned by policymakers and practitioners to guide their decisions. They can also be used to determine the causal relationship between an intervention and its results. However, they should not be used in lieu for the use of explanation trials.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials can replace tests for 프라그마틱 무료체험 메타 explanations or if they are a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decisions. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic study that include the recruitment process, the design and delivery of the intervention, 무료슬롯 프라그마틱 and the follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary care settings.